FIT screening

Colorectal cancer (CRC) is one of the most frequently diagnosed cancers. The good news is that CRC incidence and mortality can be reduced significantly if detected early enough.

Faecal immunochemical tests (FIT) are non-invasive and can detect blood in stool invisible to the naked eye. Due to its simplicity, FIT is currently considered the best non-invasive test for CRC screening.

Invest a little time in your own health by taking the FIT to prevent or detect colon cancer early on.
For further information, please visit our ‘FIT for screening’ website www.fitscreening.eu/patients

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RET/PLT-O Channel

In the RET/PLT-O channel, the surfactant in RET-SEARCH (II) slightly perforates the cell membranes of red blood cells, white blood cells and platelets and so allows the fluorescence marker to penetrate the cell. The fluorescence marker then labels the nucleic acids in white blood cells, NRBC, reticulocytes and platelets. Using the forward scattered light and the fluorescence signal, the reticulocytes can be separated from mature red blood cells, white blood cells and NRBCs.

According to their fluorescence intensity, reticulocytes are fractionated into three categories, representing different stages of maturity:

  • LFR (low fluorescence reticulocytes)
  • MFR (medium fluorescence reticulocytes)
  • HFR (high fluorescence reticulocytes)


The IRF (immature reticulocyte fraction) reflects the proportion of immature reticulocytes and is calculated from the sum of MFR plus HFR.

The RET channel also provides the optical platelet count and is available on the XT-2000i, XT-4000i, XE-2100 and XE-5000 haematology analysers.

Fluorescence flow cytometry

WBC differential channel

DC sheath flow detection method

SLS detection
method

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