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This white paper intents to give an overview of the most common types of anaemia with a focus on how haematological parameters such as RET-He and other advanced RBC parameters help to distinguish different causes of anaemia. The white paper also summarises current guidelines and publications on advanced RBC parameters in order to help clinicians in choosing the appropriate treatment for the individual patient.
Haemostasis is a complex process that helps to keep the blood in a fluid state and prevent blood loss at the site of injury. While the intact endothelium of blood vessels has an anti-thrombogenic function that prevents blood coagulation, in the case of vessel wall damage, the exposed sub-endothelial components initiate the formation of a clot that will stop blood loss.
The detection of blast cells in the peripheral blood is considered extremely important, and great responsibility is placed on the investigating laboratory. As well as informa¬tion on the physiology, this SEED article describes the possible causes of the release of blast cells into the blood, the char¬acteristics by which they can be identified and how further diagnosis is carried out.
With this clinical case report an example of a rare blastic plasmacytoid dendritic neoplasm (BPDCN) as it occurred on the XN-Series analyser is described. The measurements were carried out directly after treatment and three months later. The distribution of WBC in the WDF scattergrams were abnormal and the XN analyser indicated these abnormalities with the flags ‘Blasts?’ and ‘Abn Lympho?’ and the subsequent manual smear review revealed the presence of blasts.
Follicular lymphoma (FL) is the most common form of indolent lymphoma in the western world, accounting for approximately 25% of malignant lymphomas (Ciabanu et al 2013). Disease progression of FL is often unpredictable with 25% - 30% of FL cases progressing; most commonly to diffuse large B cell lymphoma, Hodgkin lymphoma, Burkitt lymphoma and rarely B-lymphoblastic leukaemia/lymphoma (B-ALL) (Swerdlowetal, 2017).
This clinical case reports the disease progression of a patient hospitalised due to a SARS-CoV-2 infection. The patient’s condition worsens significantly over time, ultimately leading to the development of an acute respiratory distress syndrome (ARDS), a common but very severe complication in respiratory tract infections (such as COVID-19).