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The art of defining reference intervals

To interpret the result of a blood count, a physician needs reference intervals from healthy people alongside the results of the analysis. The challenge is to define a ’healthy’ reference cohort. Common diseases with a long latency period, such as anaemia, are not recognised by individuals and therefore cannot be determined via questionnaires. The LAVE approach, explained in detail in the SEED, offers the possibility to exclude exactly these individuals from the reference cohort. The SEED lists reference intervals for adults for 105 parameters of XN-Series analysers based on a Dutch cohort.
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