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In patients treated with haemodialysis (HD), the interaction with the dialysis membrane can disturb haemostatic balance. Interaction of platelets with the membrane can lead to platelet activation and adhesion, which both affects membrane performance and the viability of platelets. By looking at platelet characteristics and morphology, as well as markers of platelet activation, this process can be characterized in more detail.
This SEED article is meant to explain the findings focused on cell count and differentiation for pleural, ascitic, cerebrospinal and synovial fluid as well as for CAPD. Traditionally, body fluid counts are performed by manual counting under a microscope using a haemocytometer, but laboratories now have the option of automating their manual processes using automated haematology or urinalysis analysers. This SEED summarises the advantages and disadvantages of haemocytometry and Sysmex analysers and explains briefly the XN-BF mode.
Cerebrospinal fluid as sample material requires particular attention at all times, from sample collection and transport to laboratory diagnostics. Upon arrival at the laboratory, the CSF sample must be processed quickly with great care and expertise so that the analysis results provide the information needed by the physician for treatment decisions. In this article you find a summary of all lab procedures with a focus on cell count and differentiation.